CareLit Fachartikel
The Use of Large Animal Models in Trauma and Bleeding Studies
Rayatdoost, F.; Grottke, O. · Zeitschrift für Orthopädie und Unfallchirurgie · 2023 · Heft 05 · S. 360 bis 373
Dokument
613722
CareLit-ID
Jahr
2023
Publikation
PDF
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Metadaten
DOI
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zitierfähig
Bibliografische Angaben
Zusammenfassung
Abstract Background Major trauma often results in significant bleeding and coagulopathy, posing a substantial clinical burden. To understand the underlying pathophysiology and to refine clinical strategies to overcome coagulopathy, preclinical large animal models are often used. This review scrutinizes the clinical relevance of large animal models in hemostasis research, emphasizing challenges in translating findings into clinical therapies. Methods We conducted a thorough search of PubMed and EMBASE databases from January 1, 2010, to December 31, 2022. We used specific keywords and inclusion/exclusion criteria…
Schlagworte
Models
Animal
Studies
Large
Trauma
Clinical
Hemorrhage
Bleeding
Often
Results
Coagulopathy
Pathophysiology
Zeitschrift für Orthopädie und Unfallchirurgie
