CareLit Fachartikel

Extracellular nucleic acids as novel alarm signals in the vascular system

Fischer, S.; Preissner, K.-T. · Zeitschrift für Orthopädie und Unfallchirurgie · 2013 · Heft 01 · S. 37 bis 42

Dokument
615026
CareLit-ID
Jahr
2013
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Orthopädie und Unfallchirurgie
Autor:innen
Fischer, S.; Preissner, K.-T.
Ausgabe
Heft 01 / 2013
Jahrgang 33
Seiten
37 bis 42
Erschienen: 2013-01-01 00:00:00
ISSN
0720-9355;2567-5761
DOI
10.5482/hamo-13-01-0001

Zusammenfassung

SummaryUpon vascular injury or tissue damage, the exposed intracellular material such as nucleic acids, histones and other macromolecules may come into contact with vessel wall cells and circulating blood cells and may thus, have an enduring influence on wound healing and body defence processes. This short review summarizes recent work related to extracellular DNA and RNA and their role as prominent alarm signals and inducers of different defence reactions related to innate immunity and thrombus formation. Of particular importance are DNA-histone complexes (nucleosome material) that, having been expelled during…

Schlagworte

Blood Blood Coagulation Blood Cells Cytokines Bacteria Work Zeitschrift für Orthopädie und Unfallchirurgie