Mouse models to study von Willebrand factor structure-function relationships in vivo
Marx, I.; Badirou, I.; Pendu, R.; Christophe, O.; Denis, C.-V. · Zeitschrift für Orthopädie und Unfallchirurgie · 2009 · Heft 01 · S. 17 bis 20
Bibliografische Angaben
Zusammenfassung
SummaryVon Willebrand factor (VWF) structure-function relationship has been studied only through in vitro approaches. The VWF-deficient mouse model has been extremely useful to examine the in vivo function of VWF but does not allow a more subtle analysis of the relative importance of its different domains. However, considering the large size of VWF and its capacity to interact with various ligands in order to support platelet adhesion and aggregation, the necessity to evaluate independently these interactions appeared increasingly crucial. A recently developed technique, known as hydrodynamic injection, which al…
