Protein-Z-Mangel bei ungeklärter Neigung zu Thrombosen, Blutungen oder Aborten

SummaryA protein Z deficiency is presumably related with a threefold risk of venous and arterial thrombosis. Mucosal bleedings and post-operative haematomas can occur more frequently. This is seen in an increased in vivo bleeding time without other plasmatic coagulation disorders or thrombopathies. Pregnancy complications, especially abortions before the 15th week of gestation, are described as well. Patients, methods: Since May 2011 the plasmatic concentration of protein Z has been tested in 684 patients of the Hämostaseologicum. Results: In 74 patients a protein Z deficiency has been found. In other 45 patient…