CareLit Fachartikel

New anticoagulants for secondary haemostasis

Nowak, G. · Zeitschrift für Orthopädie und Unfallchirurgie · 2009 · Heft 03 · S. 256 bis 259

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616111
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Jahr
2009
Publikation
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Orthopädie und Unfallchirurgie
Autor:innen
Nowak, G.
Ausgabe
Heft 03 / 2009
Jahrgang 29
Seiten
256 bis 259
Erschienen: 2009-01-01 00:00:00
ISSN
0720-9355;2567-5761
DOI
10.1055/s-0037-1617034

Zusammenfassung

SummaryIn contrast to heparins and oral anticoagulants, anti IIa inhibitors (thrombin inhibitors) are able to directly inhibit the protease activity of thrombin and can thereby precisely control the blood coagulation process.Direct thrombin inhibitors are either biosimilars (r-hirudin) or synthetically produced substances (bivalirudin, argatroban, dabigatran). In 1997 r-hirudin was introduced into clinical practice, however due to its narrow therapeutic range and the necessity of drug monitoring it has not gained widespread clinical use by now. Since 2004 and 2005 the synthetic thrombin inhibitors bivalirudin an…

Schlagworte

Blood Coagulation Dabigatran Blood Anticoagulants Drug Monitoring Zeitschrift für Orthopädie und Unfallchirurgie