Untersuchungen zur Hämostase bei Kindern unter Valproatbehandlung
Schädlich, D.; Friebel, D.; Schallner, J.; Gehrisch, S.; Siegert, G.; Kuhlisch, E.; Knöfler, R. · Zeitschrift für Orthopädie und Unfallchirurgie · 2010 · Heft S 01 · S. S132-S137
Bibliografische Angaben
Zusammenfassung
SummaryCoagulation parameters were determined in children with valproic acid mono- and valproic acid-lamotrigin combination therapy. Patients, methods: Monotherapy group (n = 22; mean age: 10.5 years) was compared to combination therapy (n = 7; 12.9 years) and a control group (n = 22; 8.7 years). The following parameters were measured: aggregation and ATP-release in whole blood (ADP: 20 μmol/l, collagen: 1 μg/ml, thrombin: 0.5 U/ml), PFA-100® closure times (CT), blood cell counts, global tests, VWF : Ag, VWF : CBA, factors VIII and XIII as well as fibrinogen. Bleeding symptoms were evaluated by using a questionn…
