High Prevalence of Acquired Platelet Secretion Defects in Multiple Myeloma
Swieringa, F.; Sang, Y.; Remijn, J.-A.; Fijnheer, R.; Korporaal, S.-J.-A.; Urbanus, R.-T.; Huskens, D.; Konings, J.; Li, L.; de Laat, B.; Roest, M. · Zeitschrift für Orthopädie und Unfallchirurgie · 2025 · Heft 2 · S. 1 bis 1
Bibliografische Angaben
Zusammenfassung
AbstractThrombocytopenia at admission predicts mortality in multiple myeloma (MM) and might link to disease progression. Although thrombocytopenia is known to be associated with MM, a possible thrombopathy is clinically less known. We conducted a case–control study comparing platelet responses of MM patients to controls via flow cytometry, integrin αIIbβ3 activation and P-selectin exposure, and a bioluminescent assay, ATP release. No difference was found at baseline, but upon platelet stimulation, MM patients had decreased αIIbβ3 activation, partly impaired P-selectin exposure, and reduced δ-granule (ATP) secret…
