Atherothrombotic risk in obesity
Vera, R.; Vilahur, G.; Badimon, L. · Zeitschrift für Orthopädie und Unfallchirurgie · 2013 · Heft 04 · S. 259 bis 268
Bibliografische Angaben
Zusammenfassung
SummaryA link between obesity and coronary artery disease development has been repeatedly proposed, possibly in part due to the development of a proinflammatory and prothrombotic state in obese subjects. Adipocytes secrete numerous hormones and cytokines (adipokines) which influence gene expression and cell functions in endothelial cells, arterial smooth muscle cells, and monocytes/macrophages favouring the development of an atherosclerotic vulnerable plaque. Moreover, the release of such biologically active molecules also promotes endothelial function impairment, disturbs the haemostatic and fibrinolytic system…