CareLit Fachartikel

Mechanism of action of Lupus anticoagulants

Arnout, J. · Zeitschrift für Orthopädie und Unfallchirurgie · 2001 · Heft 02 · S. 44 bis 49

Dokument
617081
CareLit-ID
Jahr
2001
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Orthopädie und Unfallchirurgie
Autor:innen
Arnout, J.
Ausgabe
Heft 02 / 2001
Jahrgang 21
Seiten
44 bis 49
Erschienen: 2001-01-01 00:00:00
ISSN
0720-9355;2567-5761
DOI
10.1055/s-0037-1619504

Zusammenfassung

SummaryThe antiphospholipid syndrome (APS) is defined as the association of antiphospholipid antibodies (aPL) with thrombosis, fetal loss or thrombocytopenia. Some aPL can be detected via coagulation assays where they present as an aspecific inhibitor termed the lupus anticoagulant (LA). Others can be measured via direct binding to cardiolipin and are termed anticardiolipin antibodies. aPL found in APS patients bind to a variety of PL-binding proteins such as beta-2-glycoprotein I (β2GPI) and prothrombin bound to PL surfaces. LA retard coagulation reactions in vitro by forming stable bivalent immune complexes on…

Schlagworte

Antibodies Antiphospholipid Syndrome beta 2-Glycoprotein I Association Work Anticoagulants Zeitschrift für Orthopädie und Unfallchirurgie