CareLit Fachartikel

Signal Transduction and Transformation by the Platelet Activation Cascade: Systems Biology Insights

Sveshnikova, A.-N.; Panteleev, M.-A. · Zeitschrift für Orthopädie und Unfallchirurgie · 2025 · Heft 01 · S. 049 bis 062

Dokument
617460
CareLit-ID
Jahr
2025
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Orthopädie und Unfallchirurgie
Autor:innen
Sveshnikova, A.-N.; Panteleev, M.-A.
Ausgabe
Heft 01 / 2025
Jahrgang 45
Seiten
049 bis 062
Erschienen: 2025-02-01 00:00:00
ISSN
0720-9355;2567-5761
DOI
10.1055/a-2486-6758

Zusammenfassung

AbstractBinding of platelet activators to their receptors initiates a signal transduction network, where intracellular signal is filtered, amplified, and transformed. Computational systems biology methods could be a powerful tool to address and analyze dynamics and regulation of the crucial steps in this cascade. Here we review these approaches and show the logic of their use for a relatively simple case of SFLLRN-induced procoagulant activity. Use of a typical model is employed to track signaling events along the main axis, from the binding of the peptide to PAR1 receptor down to the mPTP opening. Temporal dyna…

Schlagworte

Calcium Biology Algorithms Address Axis Zeitschrift für Orthopädie und Unfallchirurgie