Role of coagulation and fibrinolysis in lung and renal fibrosis
Ruppert, C.; Markart, P.; Wygrecka, M.; Preissner, K.-T.; Günther, A. · Zeitschrift für Orthopädie und Unfallchirurgie · 2008 · Heft 01/02 · S. 30 bis 36
Bibliografische Angaben
Zusammenfassung
SummaryElevated procoagulant and suppressed fibrinolytic activities are regularly encountered in different forms of clinical and experimental fibrosis of the lungs and the kidneys. Although primarily serving to provide a provisional matrix of repair largely consisting of fibrin and fibronectin, the involved procoagulant serine proteases and protease inhibitors may also exert distinct cellular downstream signaling events modifying the fibrotic reponse.In this review, evidence for an impaired regulation of coagulation and fibrinolysis factors in clinical and experimental lung and renal fibrosis is provided and the…
