HIV DNA Vaccination: Advances and Experiences
Fernando, K.-P.; Muthumani, K.; Zhang, D.; Kudchodkar, S.; Weiner, D.-B. · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · 2001 · Heft 11 · S. 1076 bis 1082
Bibliografische Angaben
Zusammenfassung
The world is in dire need of a vaccine against HIV. Several approaches for vaccine development have been taken to eradicate this deadly virus. DNA vaccines in particular are being considered as prime candidates for this task. The ease with which they can be molecularly manipulated, compounded by their immunogenicity, safety, and simple and reproducible manufacture, have put DNA vaccines in the vaccine spotlight. Co-transfection of plasmids encoding HIV antigens, with those having the potential to veer the immune response in the desired direction (cytokines, chemokines, and co-stimulatory molecules), have shown p…
