Immunogenicity of a recombinant coronavirus spike glycoprotein expressed in transgenic plants
Escribano, J.-M.; Borca, M.-V. · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · 2000 · Heft 2 · S. 110 bis 115
Bibliografische Angaben
Zusammenfassung
Recently, it has been demonstrated that plants offer the possibility of producing low cost subunit vaccines that can be either parenterally or orally administered. Here we review data we obtained on the immunological response elicited by two recombinant versions of the glycoprotein S from the swine transmissible gastroenteritis coronavirus (TGEV) expressed in transgenic plants. Arabidopsis or potato plants were genetically transformed with cDNAs constructs encoding the N-terminal domain (aa residues 1–750) or the full-length glycoprotein S of TGEV, responsible for the neutralizing antibody induction against the…
