Plant-based cholera toxin B subunit-insulin/GAD fusion pro-teins suppress the development of autoimmune diabetes
Befus, N.; Langridge, W.-H.-R. · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · 2000 · Heft 2 · S. 116 bis 120
Bibliografische Angaben
Zusammenfassung
Insulin-dependent diabetes mellitus (IDDM) is a T lymphocyte mediated organ-specific autoimmune disease in which pancreatic islet inflammation (insulitis) destroys the insulin-producing β-cells leading to a permanent increase in blood sugar levels (hyperglycemia). Principal self antigens recognized by the T-cells are glutamic acid decarboxylase (GAD) and insulin (INS), with GAD being the initiating antigen. Oral administration of pancreatic self antigens generate partial suppression of both insulitis and hyperglycemia symptoms. To expedite targeting of self antigens to the mucosal immune system, the 11.6 kDa non…
