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Characterization of the post-translational biochemical processing of human lactoferrin expressed in transgenic tobacco

Spik, G.; Theisen, M. · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · 2000 · Heft 2 · S. 104 bis 109

Dokument
674955
CareLit-ID
Jahr
2000
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
Autor:innen
Spik, G.; Theisen, M.
Ausgabe
Heft 2 / 2000
Jahrgang 43
Seiten
104 bis 109
Erschienen: 2000-02-01 00:00:00
ISSN
1437-1588
DOI
10.1007/s001030050019

Zusammenfassung

During the last couple of years it has been shown that transgenic plants are suitable host organisms for the production of recombinant mammalian proteins of therapeutic interest. Using transgenic tobacco plants as an experimental system we demonstrated that human lactoferrin, an iron-binding glycoprotein, is an interesting target molecule for this production system. Nonoptimized expression/extraction levels of up to 0.3% have so far been obtained. The recombinant human lactoferrin possesses similar molecular mass to native human milk lactoferrin but differs by its carbohydrate moiety. As this difference in glyco…

Schlagworte

Lactoferrin Human Transgenic Plants Production Recombinant System Tobacco During Couple Years Shown Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz