Nociceptin in experimentally induced hepatocellular carcinoma
A Horváth, A Folhoffer, T Csák, A Zalatnai, M Hantos, K Tekes, PL Lakatos, F Szalay · Zeitschrift für Gastroenterologie · 2004 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background/aim: Nociceptin (N/OFQ) is the endogenous agonist of opioid-like 1 receptor (ORL1) named as OP4. High plasma N/OFQ level has been reported in Wilson disease and in patients with hepatocellular carcinoma (HCC). We investigated N/OFQ in experimentally induced HCC. Methods: HCC was induced in male F-344 rats by diethylnitrosamine (DEN)+Phenobarbital (PB)+carbon tetrachloride (CCl4) as published earlier. A total of 30 male F-344 rats were involved. Animals were divided into three groups. Group 1 (n=8, served as control), group 2 (n=5, treated with DEN+PB) and group 3 (n=8, treated with DEN+PB+CCl4). The a…
