NOD2/CARD15 SNP8, 12 and 13 and other EXON4 mutations and primary biliary cirrhosis (PBC) in Hungarian and Polish patients
PL Lakatos, C Willheim-Polli, A Folhoffer, A Horvath, T Csák, C Österreicher, A Habior, I Tornai, P Ferenci, F Szalay · Zeitschrift für Gastroenterologie · 2004 · Heft 05
Bibliografische Angaben
Zusammenfassung
Mutations of the NOD2/CARD15 gene –coding a bacterial LPS receptor- were identified as genetic markers for Crohn's disease (CD). PBC shares some features of CD (e.g. possible infectious etiology, granulomas). It has been suggested that infection by bacteria and cross-reactivity between bacterial and self-proteins may be an important factor in the pathogenesis. In this study the presence of common NOD2/CARD15 mutations were investigated in Hungarian and Polish PBC patients. Patients and methods: 88 patients with PBC (each female, mean age: 61.4 (SD 9.6) years) were included in this study. A set of 200 healthy blo…
