The examination of the mutations in the NOD2 gene in Hungarian Crohn's disease patients and healthy controls

Introduction: The development of Crohn's disease is influenced by genetic, autoimmun and environmental factors. The inflammatory bowel disease is linked to 8 gene loci (IBD1–8). Most notable is the association of the NOD2 gene in IBD1 locus to Crohn's disease. Certain polymorphisms of the NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC) are most common in Crohn's disease. NOD2 is a disease-resistance gene and regulator of the response to lipopolysaccharides found in bacteria. Aim: The allele frequency of the Gly908Arg and Leu1007fsinsC mutations were evaluated in Crohn's disease patients and healthy controls.…