Oral fluoropirimidine treatment of heavily pretreated advanced colorectal cancer patients

Introduction: The purpose of this study was to establish the feasibility and efficacy of oral fluoropirimidine monotherapy in the treatment of advanced CRC patients failing conventional 5-fluorouracil, irinotecan and oxaliplatin containing regimen. Patients and methods: Between 28 March 2003 and 12 February 2004, 25 advanced CRC patients were treated with oral fluoropirimidine monotherapy. 16 (3-UFT /13-Xeloda group) patients who had passed their first staging examinations were evaluated. Patients received tegafur 300mg/m2/d, uracyl 672mg/m2/d and leucovorine 90mg/m2/d days 1 to 28 every 5 weeks in the UFT group…