Stress induced Visceral Hypersensitivity: Modulation by preceding mucosal Inflammation and role of Neurokinin Receptors

Aims: Altered processing of visceral afferent information is believed to play a key role for the manifestation of patients in at least a subgroup of patients with functional gastrointestinal disorders. However, underlying mechanisms are poorly understood, while it is well recognized that there are initiating events such as mucosal inflammation and stress that obviously precipitate the onset of symptoms. Aims: We aimed to study the role of mucosal inflammation and a repeated standardized stressor on visceral sensory function and the link to Neurokinin (NK) receptor expression. Methods : In randomized order, trini…