CareLit Fachartikel
CYP2C19 Polymorphism and proton pump inhibitors (PPI) in Helicobacter Pylori eradication therapy–A Metaanalysis
GG Treiber, M Schwab, U Klotz · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Dokument
801878
CareLit-ID
Jahr
2004
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: PPI are metabolised by the polymorphic CYP2C19. H.pylori eradication results according to different PPIs and dosages are inconsistent. Data from asian studies suggested that poor metabolisers of PPIs do better, data in caucasians are scarce. Objective/Methods: Meta-analysis of available literature data. Results: By mid of 2003, 12 studies met the inclusion criteria and reported differences in eradication outcome between wt/wt (wildtype, extensive metabolisers) vs. combined wt/mt and mt/mt (mutant, deficient metabolisers) alleles. Significant (p=0.0012) heterogeneity could be observed and was resolved (p=0.…
Schlagworte
CYP2C19
Eradikation
Helicobacter pylori
Metaanalyse
Metabolisierung
Protonenpumpenhemmer
Zeitschrift für Gastroenterologie
