Nuclear survivin is a powerful novel prognostic marker in gastroenteropancreatic neuroendocrine tumour disease
P Grabowski, S Griß, CN Arnold, D Hoersch, R Göke, R Arnold, B Heine, H Stein, M Zeitz, H Scherübl · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background–Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) represent a rare and rather heterogeneous tumour entity. The growth pattern of GEP-NETs ranges from very slowly to fast growing, aggressive types of tumours. Survivin, a member of the family of apoptosis inhibitors, is a bifunctional protein that suppresses apoptosis and regulates cell division. Aims–Here we determined the prognostic value of survivin in a series of GEP-NETs. Patients and Methods–Tumour specimens from 104 patients (38 foregut, 53 midgut, 13 hindgut NETs) were studied immunohistochemically for cytoplasmic and nuclear survivin exp…
