CareLit Fachartikel

Characterization of denritic cell subsets in HCV patients treated with interferon-alpha

VR Cicinnati, S Beckebaum, X Zhang, K Koop, Z Yu, X Chen, A Frilling, C,E Broelsch, G Gerken · Zeitschrift für Gastroenterologie · 2004 · Heft 08

Dokument
801903
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Jahr
2004
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
VR Cicinnati, S Beckebaum, X Zhang, K Koop, Z Yu, X Chen, A Frilling, C,E Broelsch, G Gerken
Ausgabe
Heft 08 / 2004
Seiten
–
Erschienen: 2004-08-18 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-831770

Zusammenfassung

Dendritic cells (DC) play a central role in the induction and regulation of an efficient antiviral immune response. The CD11cpos myeloid DC (MDC) including the BDCA–1 and BDCA–3 subpopulations and CD11cneg, CD123pos plasmacytoid DC (PDC) represent the main subsets of circulating DC based on functional and phenotypic differences. We determined the frequency and phenotype of DC subsets in the peripheral blood from 48 patients with chronic hepatitis C (HCV) infection with and without interferon-alpha treatment. Three color flow-cytometric analysis revealed that the percentage of MDC from untreated HCV patients was…

Schlagworte

blood dendritic cell antigen interferon-alpha myeloid DC plasmacytoid DC Zeitschrift für Gastroenterologie