Epidemiology and Genetics of Alzheimer Dementia

Alzheimer dementia (AD) affects over 650,000 people in Germany and is the most common form of aging-related dementia. Mutations in the presenilins (PS1, PS2) and amyloid precursor protein (APP) are causative in rare forms of autosomal dominant familial Alzheimer disease (FAD). These findings contributed significantly to the current concept of the pathogenesis of AD. Whereas FAD accounts for