Intraindividual Long-Term Stability of BOLD Response within the Mesial Temporal Lobe (MTL)

Functional MRI allows one to study pharmacological treatment effects (Leslie & James, 2000). Long-acting drugs, such as antiepileptic drugs, require measurement designs which are stable over time. Therefore, we investigated the long-term within-subject stability of the BOLD response across several sessions. Six healthy volunteers (five males, one female, aged 24–31 years) were examined six times with a modified version of the Roland hometown walking task (Jokeit et al., 2001): Four measurements were performed at four different days within an interval of 1–4 weeks (between-day measurements). On the first and the…