Cabergoline versus pergolide in levodopa-treated Parkinson's disease patients with nocturnal disabilities: a randomised, double-blind crossover trial to evaluate efficacy, tolerab…

Sleep disorders in PD patients often are caused by complications of levodopa therapy like motor fluctuations in response or abnormal involuntary movements. These may appear as early morning dystonia, pain and spasm at night, nocturnal akinesia, nocturia and nocturnal treatment-related psychotic episodes, namely hallucinations. Method: In a double-blind, randomised, bi-centre, crossover design, patients with idiopathic PD and nocturnal disabilities were up-titrated in the first crossover period (2 weeks) to an individually optimised dose of CBG (maximum dose: 6mg) or PGL (maximum dose: 5mg, given in 3 doses). Aft…