Hormonal impact on oxidative phosphorylation – androgen receptors during estrus-cycle dependent hypoxic tolerance

Incidence of cerebrovascular disease is higher in men compared to women during total life span. It is known for years that in women primary hypoxic tolerance is modulated endogenously during estrous cycle. Therefore intensive investigations have been done to clarify the role of estrogen and progesterone on oxidative phosphorylation and neuroprotection. However only little is known about the impact of testosterone on neuronal survival. Only a few data have been observed suggesting deleterious neuronal effects of androgens, mostly said to be mediated via progression of arteriosclerosis and endothelian dysfunction.…