Prevention of AIDS dementia by HAART does not depend on CSF drug penetrance – an event-related potential study

The impact of the CSF penetrance properties of different HAART regimes on cognitive processing in AIDS dementia is still undetermined. We therefore designed a retrospective cross-sectional and prospective longitudinal analysis of event-related potentials in HIV infected patients with different combinations of HAART or without antiretroviral treatment. 353 consecutive patients without secondary CNS manifestation of HIV infection were enrolled in the cross-sectional study and 135 consecutive patients without secondary CNS manifestations of HIV infection were enrolled in the longitudinal study. HAART in different c…