Targeted Combination Therapy for the Treatment of Primary Pulmonary Arterial Hypertension

Introduction: The treatment of severe primary pulmonary arterial hypertension (PAH) aims to avoid deterioration with the necessity of lung transplantation or continuous administration of pulmonary vasodilators, or even to reverse the course. Case report: A 42-year-old patient had had dyspnea, anginal symptoms and exercise impairment for 2 years and was currently in NYHA class III. Maximal oxygen uptake was 13,1ml/kg*min, VE/VCO2 36 L/L, and the 6min walk test 375 m. Heart catheterization showed a pulmonary arterial pressure of 120/40mmHg (mean 75mmHg), and pulmonary vascular resistance of 29,6 WU*m2, which could…