Therapeutic implications of screening MDR1/MRP1 activity in peripheral lymphocytes in inflammatory bowel disease
K Illés, E Schäfer, T Micsik, O Szokolóczi, B Bránné Németh, A Gelley, R Vernes, T Gyökeres, Á Pap, I Peták, R Schwab · Zeitschrift für Gastroenterologie · 2005 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: Most current drugs to treat inflammatory bowel disease (IBD) including corticosteroids, azathioprine, cyclosporine are substrates of ABC-MDR transporters. These proteins significantly alter intracellular drug availability and thus efficacy. Our aim was to retrospectively assess therapeutic responsiveness of relapsing CD/UC to the applied steroid/AZA doses in view of the patient's MDR profile. Patients & Methods: 50 patients were included in the study: 35 pts had Crohn's disease and 15 pts had ulcerative colitis. 24% of pts were non-responsive to conventional pharmacotherapy, 22% of them were currently on s…
