Active vitamin-D treatment in patients with Crohn's disease complicated

Introduction: Osteoporosis is a well known complication of Crohn's disease (CD). The most important factors in this field are the alterations of vitamin-D and calcium (Ca) homeostasis. Some recently developed biochemical markers are suitable to evaluate the efficacy of the therapy. Beta-CrossLaps (bCL) is indicative for bone resorption, while osteocalcin (OC) characterises bone formation. The tendency of bone turnover above all depends on the ratio of osteoprotegerin (OPG) and receptor activating NF-κ-B ligand (RANKL). Aim: Our aim was to evaluate the difference of the antiporotic therapy using conventional (cVD…