Assessment of MDR1/MRP1 transporter function in lymphocyte-subpopulations of inflammatory bowel disease
E Schäfer, I Peták, T Micsik, K Illés, O Szokolóczi, B Bránné Németh, A Gelley, R Vernes, T Gyökeres, Á Pap, R Schwab · Zeitschrift für Gastroenterologie · 2005 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Most current drugs to treat inflammatory bowel disease (IBD) including corticosteroids, azathioprin (AZA), cyclosporine are substrates of ABC-MDR transporters. These proteins significantly alter intracellular drug availability and thus efficacy. Our aim was to determine the CD markers of choice to monitor induction of ABC-transporter proteins in IBD patients. Patients & Methods: 50 patients were included in the study: 35 pts had Crohn's disease and 15 pts had ulcerative colitis. 24% (12/50) of pts were non-responsive to conventional pharmacotherapy, 22% (11/50) of them were currently on steroids. 33%…
