Toxicity profile of adjuvant treatment according to Mayo protocol in colorectal cancer patients

Introduction: We analyzed the tolerability of Mayo protocol in a prospective study. Patients and study design: 103 stage II/III CRC patients who previously had undergone colon resection with curative intent were treated according to Mayo protocol at our department between May 2003 and September 2004. The average age was 62 ys (37–81), 49 men and 54 women were treated. On days 1.-5. of each cycle 20mg/m2 Leucovorin, 425mg/m2 5-FU bolus infusion was administered in 28 days cycle. 6 cycles were to administer starting the treatment. Results: Regarding gastrointestinal side effects in 37 patients stomatitis, in 47 pa…