FIRST LINE SOFTMARKERS IN ROUTINE SCREENING – UNACCEPTABLE HIGH INCIDENCE

Problemstellung: Softmarkers as indicators of chromosomal abnormalities of the fetus are described for more than 15 years now. The main problems of softmarkers are, that they are usually published as sonographic phenomenon in high risk pregnancies prior to amniocentesis. So the positive predictive value is usually overestimated when applied to a screening population. On the other hand, many of those in between almost inumerable softmarkers occur quite often in normal fetuses causing unnecessary anxiety in the mother to be. Methoden: We evaluated prospectively the occurrence of softmarkers in a medium risk popula…