A abnormal CFTR allele and a SPINK1 mutation increase the risk of pancreatic disease in individuals with pancreas divisum
J Ockenga, A Schmidt, H Abou-Rebyeh, R Hintze, J Rosendal, HHJ Schmidt, P Asbach, H Lochs, H Witt · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Pancreas divisum (PD) has been described as a risk factor for recurrent pancreatitis or chronic pancreatitis. There is still a controversy of the role of PD in developing pancreatic disease. The aim of this study was to elucidate genetic and environmental risk factors in patients with PD. Methods: In this case control study 63 patients (female29; male 34) with recurrent acute or chronic pancreatitis without any other known reason except for PD, 18 patients with an asymptomatic PD, and 240 healthy controls were enrolled. Patients were screened for 36 alterations of the cystic fibrosis transmembrane conductance re…
