The insulin-like growth factor receptor is a promising target for innovative treatment approaches of hepatocellular cancer

Background & Aims: Hepatocellular carcinoma (HCC) is one of the most common cancer-related causes of death worldwide. Due to very poor 5-year-survival new therapeutic approaches are uregently needed. Most HCCs express insulin-like growth factors and their receptors (IGFR). As IGF–1R-mediated signaling promotes survival, oncogenic transformation and tumor growth and spread, it represents a potential target for innovative treatment strategies of HCC. Here we studied the effects of a novel IGF–1R tyrosine kinase inhibitor in human HCC cells and focused on the antineoplastic efficacy of IGF-receptor inhibition alone…