Reduced expression of SOCS3 predicts poor outcome in epithelial ovarian cancer
V Heinzelmann-Schwarz, M Gardiner-Garden, D Fink, R Sutherland, P O'Brien, N Hacker · Geburtshilfe und Frauenheilkunde · 2005 · Heft 10
Bibliografische Angaben
Zusammenfassung
Aims: Understanding the molecular basis of epithelial ovarian cancer (EOC) is critical to the identification of new prognostic markers and therapeutic targets. Interleukin-6 (IL-6) is an important regulator of ovarian cancer growth and survival. IL-6 signal transduction is mediated via the Jak/STAT pathway, resulting in activation of the transcription factors STAT1 and STAT3, and subsequent transcription of STAT-responsive genes. IL-6 signaling is specifically inhibited by suppressor of cytokine signaling 3 (SOCS3). STAT3 is constitutively activated in EOC cells and is thought to contribute to their sustained pr…
