Proteinprofiling discriminates steroid hormone receptor positive and negative ductal invasive breast cancer

Aims: Ovarian steroids, acting through nuclear receptors, are crucial players in normal breast development and cancer. Approximately 70% of all breast cancers depend on estrogen stimulation and on a functional estrogen receptor (ER). Estrogen negative tumours often overexpress genes encoding for non steroid growth factors and receptors. Complex interactions with signalling pathways and cell cycle control might explain resistance to endocrine treatment and might lead to novel therapeutic targets. Methods: From 36 ER+ and 36 ER- snap frozen ductal invasive breast carcinoma tissues, peptide extracts were generated.…