Expression and function of the four and a half LIM-only protein 2 (FHL2) in breast cancer

Aims: In Germany every year 43.000 novel cases of breast cancer develop. In order to identify novel molecular targets for the treatment of breast cancer, we investigated the function of the transcriptional Cofactor FHL2 in breast cancer cells. FHL2 belongs to the expanding family of proteins that possess highly conserved double Zn-finger motifs and are involved in protein-protein interactions and transcriptional regulation. Many studies indicate a connection of FHL2 with the tumor biology. Its expression has been shown to be increased in tumors of epithelial and melanoma cell origin. To date little is known abou…