HLA-A26 restricted HCV-specific CD8+ T cell responses in acute and chronic HCV infection
T Killinger, C Neumann-Häfelin, J Timm, D McKinney, HC Spangenberg, N Nazarova, S Southwood, H Blum, R Thimme · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Bibliografische Angaben
Zusammenfassung
Virus-specific CD8+ T cell responses play a major role in the antiviral immune response in hepatitis C virus (HCV) infection. In this context, it has recently been shown that the host Human Leukocyte Antigen (HLA) background plays a crucial role in the outcome of HCV infection. The HLA allele A26 is particularly interesting since it is one of the most frequent HLA alleles in Asia, present in up to 20% of the asian population and since it is associated with slow disease progression in human immunodeficiency virus (HIV) infection. Currently, there is no information available about the role of HLA-A26 in HCV infect…
