Interhemispheric interactions between M1 and PM during movement preparation

Precise interhemispheric interactions constitute a necessary neural basis for bimanual and complex unimanual coordination, because integration of sensorimotor information of both hemispheres is required. At rest, the effect of interhemispheric interactions between homologous motor cortices (M1) is largely inhibitory (Gerloff et al., J. Physiol. (Lond.) 1998; 510, 249–259). In the process of the generation of a movement, interhemispheric inhibition (IHI) between the M1 ipsilateral to the moving hand (iM1) and the M1 contralateral to the moving hand (cM1) turns into facilitation ('release of IHI') close to movemen…