Increased gray matter volume of the basal ganglia – a morphometric fingerprint of presymptomatic compensation in genetically determined parkinsonism
K Lasek, C Klein, C Gaser, R Hilker, J Hagenah, T van Eimeren, C Büchel, P Pramstaller, H Siebner, F Binkofski · Klinische Neurophysiologie · 2006 · Heft 03
Bibliografische Angaben
Zusammenfassung
Objectives: There is little knowledge about in vivo changes in the human brain that precede the onset of parkinsonism. The present study used voxel-based morphometry (VBM) to investigate brain tissue changes in asymptomatic carriers of heterozygous mutations in Parkin- and PINK1-genes, and 18F-DOPA PET to establish a possible correlation between the metabolic and morphometric status of asymptomatic Parkin and PINK1 mutation-carriers. Methods: We compared structural magnetic resonance (MR) images of asymptomatic heterozygous carriers of Parkin (n=13) and PINK1 mutations (n=10) with 23 age- and sex- matched health…
