CareLit Fachartikel
Platelet Shape Changes during Thrombus Formation: Role of Actin-Based Protrusions
Markus Bender, Raghavendra Palankar · Zeitschrift für Orthopädie und Unfallchirurgie · 2021 · Heft 01 · S. 014-021
Dokument
805496
CareLit-ID
Jahr
2021
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
AbstractPlatelet activation and aggregation are essential to limit blood loss at sites of vascular injury but may also lead to occlusion of diseased vessels. The platelet cytoskeleton is a critical component for proper hemostatic function. Platelets change their shape after activation and their contractile machinery mediates thrombus stabilization and clot retraction. In vitro studies have shown that platelets, which come into contact with proteins such as fibrinogen, spread and first form filopodia and then lamellipodia, the latter being plate-like protrusions with branched actin filaments. However, the role of…
Schlagworte
platelet
thrombus
cytoskeleton
lamellipodia
actin
Blood
Lead
After
Zeitschrift für Orthopädie und Unfallchirurgie
