Active immunization with amyloid-beta 1–42 induces severe memory impairment in healthy mice

Active immunization with Amyloid-beta 1–42 (Abeta) was shown to prevent amyloid plaque deposition in different mouse models of Alzheimer's disease (AD). These effects are undoubted, whereas evidence on the improvement of memory function is still inconsistent. Here, we identify the cognitive and immunological phenotype of healthy C57BL/6 mice challenged with active Abeta immunization. Immunization significantly altered the behavioural phenotype of mice compared to control mice receiving the immune stimulant only or Myelin oligodendrocyte glycoprotein induced EAE mice. Abeta immunized mice revealed decreased locom…