The impact of intrauterine growth retardation on glomerular filtration rate

Introduction: Intrauterine growth retardation (IUGR) is a multifactorial, pathological entity, resulting in small-for-gestational-age (SGA) newborns. These neonates have higher mortality and morbidity rates in perinatal life and are at risk for the development of adult hypertension and related cardiovascular diseases. Congenital oligonephropathy has been postulated as the primary mechanism. Objective: To determine whether IUGR is a predisposing factor for reduction of glomerular filtration rate (GFR) at birth. Methods: Clearance of amikacin (Cl) was used since clearance of aminoglycosides reflects GFR. Clinical…