Gastrointestinal side effects of mycophenolate mofetil compared to mycophenolic acid in renal transplant patients

Background: Wide range of immunosuppressive (IS) drugs is available to prevent acute rejection after renal transplantation (RTX). Mycophenolic acid blocks de novo purin synthesis. This drug is not nephrotoxic, and prevents chronic rejection. There are two drug types available: I. mycophenolate mofetil (MMF) and II. enteric coated mycophenolic acid sodium (MPA). Gastrointestinal side effects often lead to dose reduction or drug withdrawal. Patients and methods: Authors analysed data retrospective of patients underwent RTX and received either MMF or MPA in combination with calcineurin inhibitor type or antiprolife…