Linkage analysis and relatedness of maternal lines of type 1 diabetes patients: significant linkage to markers on chromosome 6, 11 and 14

Aims: Recently, we found that maternal lines of type 1 diabetics in our study area are related by about 90%. Because of this finding the idea was born that families related as closely as that may show stronger effects of non-HLA genes compared to common linkage studies done before. Methods: We analysed 36 type 1 diabetic families with 181 members from whom 88 were affected using commercially available linkage mapping sets for three chromosomes: chromosome 6 with strong genetic effect, as internal control, and chromosomes 11 and 14 with weak genetic effects. The data were statistically analysed by the transmissio…