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Pharmacodynamic properties of Viaject™: A novel rapid-acting regular human insulin

S Steiner, M Hompesch, R Pohl, P Simms, A Pfützner, T Forst, L Heinemann · Diabetologie und Stoffwechsel · 2006 · Heft 06

Dokument
806933
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
S Steiner, M Hompesch, R Pohl, P Simms, A Pfützner, T Forst, L Heinemann
Ausgabe
Heft 06 / 2006
Seiten
–
Erschienen: 2006-06-19 00:00:00
ISSN
1861-9002
DOI
10.1055/s-2006-943950

Zusammenfassung

The aim of this study was to evaluate the pharmacodynamic properties of the novel insulin formulation Viaject™ (VJ). VJ is a formulation of regular human insulin and GRAS ingredients designed to increase the rate of absorption. Five euglycemic glucose-clamps (Biostator; target blood glucose 90mg/dl) were performed in 10 fasting healthy volunteers (age 40 (20–62) years (mean (range)); BMI 22.5 (19.2–24.9)kg/m2). Using a cross-over design with a fixed treatment order, 12 IU Regular insulin (RI), 12 IU Insulin Lispro (IL) and 12, 6 and 3 IU VJ were injected subcutaneously in the abdominal region. SC injection of VJ…

Schlagworte

Diabetologie und Stoffwechsel