Ontogeny Of In Vivo Cyp3a4 Activity In The First Months Of Life
J de Hoon, A Debeer, V Cossey, R Verbesselt, D Tibboel, H Devlieger, J Van den Anker, K Allegaert · Zeitschrift für Geburtshilfe und Neonatologie · 2006 · Heft 11
Bibliografische Angaben
Zusammenfassung
Introduction: Document maturational changes of in vivo CYP3A4 activity in the first months of life. Methods: The contribution of tramadol (M), O-demethyl (M1, CYP2D6 mediated) tramadol and N-demethyl tramadol (M2, CYP3A4 mediated) to overall tramadol elimination and the log M/M2 were assessed in 24 hours urine collections during continuous intravenous tramadol administration and correlations with perinatal characteristics [postnatal age (PNA), postmenstrual age (PMA)] were investigated (1). Results: Of the total amount of M administered in a 24 hours interval, 34.5 (SD 6.1)% was retrieved in the urine as parent…
