Association of polymorphisms in the human surfactant protein-D (SFTPD) gene and pulmonary morbidity in the preterm infant

Surfactant protein-D (SP-D) is a member of the collagenous subfamily of calcium-dependent lectins (collectins). Associations between single nucleotide polymorphisms (SNPs) of the human gene coding surfactant protein-D (SFTPD) and infectious pulmonary diseases have previously been described. Outcome for the immature preterm infant is mainly determined by pulmonary morbidity. The aim of the present study was to explore the association of sequence variations within the SFTPD gene with acute and chronic pulmonary morbidity. Four validated SNPs were genotyped with sequence-specific probes in 284 newborn infants of ≤3…